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Stuart (USA authors) Very comprehensive book about B12 deficiency with lots of case studies

Specifically, HMMER allows us to identify protein sequences encoding functional domains through implementing probabilistic Hidden Markov Models (HMM) to search for protein sequence homologs against a profile database such as Pfam

Indeed, their deregulations have a direct impact on nutrients uptake, gut functionality, and microbiome, and, importantly, pancreatic enzymes alterations are directly associated to adipose tissue wasting, making it an early event in pancreatic cancer-associated cachexia (Kordes et al., 2021)

J Mol Biol 405:254273

Its always best to consult your doctor to determine the ideal B12 injection frequency for you