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FEBS Lett 1991

52 78c, as a highly specific and effective CD38 inhibitor, can reverse age-associated NAD + reduction and improve some metabolic and physiological parameters of aging, such as glucose tolerance, cardiac function, muscle function and exercise capacity in both natural aging and accelerated aging mice models

10.1016/j.nrleng.2023.05.002 69 KimY.ChaS

In the context of ovarian aging, it activates SIRT1-dependent pathways, which are critical for maintaining genomic stability, mitochondrial efficiency, and cellular survival (Pasquariello et al., 2020)