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Huang Q, Ding Y, Fang C, Wang H, Kong L

Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models

Sci Rep 2019;9:1968

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Myles BH, Wei C, Komaki R, Vaporciyan AA, Mehran RJ, SG &, Hofstetter WL, Ajani JA, Liao ZX, Cox JD, Lin SH