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Although PDI is classically regarded as an ER-resident enzyme involved in protein folding, emerging evidence from our recent studies suggests that a noncanonical pool of PDI, potentially localized in the cytosol or in close association with the mitochondria, plays a predominant role in mediating ferroptotic signaling

Rahman MM, Wang X, Islam MR, Akash S, Supti FA, Mitu MI, Harun-Or-Rashid M, Aktar MN, Khatun Kali MS, Jahan FI, Singla RK, Shen B, Rauf A, Sharma R

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

**Consistent summer heat stress for fitness-focused residents.** Austin has a deeply active running, cycling, and fitness community, and training through a Texas summer takes a real toll