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Importantly, their role in IR is not unidirectional: their pro-inflammatory outputs can impair adipocyte insulin sensitivity, yet their clearance of dead cells and debris can limit tissue-level inflammatory amplification during adipose remodeling and hepatic steatosis

Arch Med Res 23(4):163167 Aon MA, Stanley BA, Sivakumaran V, Kembro JM, ORourke B, Paolocci N, Cortassa S (2012) Glutathione/thioredoxin systems modulate mitochondrial H 2 O 2 emission: an experimental-computational study

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Conde TA, Zabetakis I, Tsoupras A, Medina I, Costa M, Silva J, et al