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Currently, researchers think the underlying mechanism could be that B6 disrupts the usual neurotransmitters responsible for preventing nerve overactivity

Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

Using the same amount multiples will give the same results, and also clear your confusion