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Hu W., Zhang C., Wu R., Sun Y., Levine A., and Feng Z., Glutaminase 2, a Novel p53 Target Gene Regulating Energy Metabolism and Antioxidant Function, Proceedings of the National Academy of Sciences of the United States of America 107, no

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In other words, high levels of lactate in the GBM TME modulates RNA splicing only in the Treg cell (Foxp3-dependent, meaning it does not affect RNA splicing in other T-cells) to increase CTLA-4 expression on the Treg cell surface, thus enhancing its immunosuppressive effects and preventing effector T-cells from infiltrating and attacking the GBM tumor cells