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For example, after systemic administration of GH for 14 days, human data have reported an increase in circulating IGF-1 and expression of IGF-1 in tendon tissue, accompanied by increased expression of tendon collagen in individuals ( in vivo studies, which have demonstrated that local administration of IGF-1 (1 mg) directly induced an elevation in collagen synthesis in human tendon tissue ( The above findings combined to demonstrate that IGF-1 is sufficient to increase collagen production in tenocytes