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Heme binding protein genes (39 genes out of the studied 121 genes) were also enriched in the upregulated gene set (Additional file 2), however substantial transcriptional changes in the case of heme biosynthesis, Fe-S cluster assembly or Fe-S cluster protein genes were not observed (Additional file 2)

Few studies have investigated these interactions, but additive protective effects have been observed when combining lithium with rapamycin or Keap1 inhibition in Drosophila models of HD and AD respectively (Sarkar et al., 2008

Immunoaffinity capture is a specialized technique used for isolating EVs by exploiting the specific interactions between antibodies and common surface proteins on the EVs such as CD9, CD63, and CD81