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To date, however, most of the aforementioned results have come from animal models, with limited human randomized controlled trials

Thats understandable, but it misses the bigger issue

The analytical certificates are for institutional review boards and grant applications to demonstrate research integrity

"IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-B signaling pathways to promote wound healing." Biomedicine & Pharmacotherapy