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10.1038/s41586-019-1705-2 5 BhatM

Sterile- Gamma Radiation

and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals

Cells dependent on GPX4 showed low expression levels of SLC7A11 of the x c system, importing cystine in exchange for glutamate (Extended Data Fig

Conversely, if you are a vegetarian or vegan, you might need to rely more on B12 shots or supplements to maintain adequate B12 levels