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The non-coenzyme action involves participation of thiamine and/or derivatives, including thiamine triphosphate, in the regulation of ACh synaptic function, consistent with the early data on thiamine as a co-mediator of ACh in neuromuscular synapses, and in allosteric action on metabolic enzymes

doi: 10.1016/j.matdes.2019.108313 223 SahinKOrhanCErBDurmusASOzercanIHSahinNet al

The tissue around the needle sees a brief high-concentration exposure before the compound dilutes through the bloodstream

Some miRNAs have been shown to modulate ferroptosis

[DOI] [PubMed] [Google Scholar] 83.Dev S, Muchenditsi A, Gottlieb A, Deme P, Murphy S, Gabrielson KL, Dong Y, Hughes R, Haughey NJ, Hamilton JP, Lutsenko S