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Association of T P53 and CDKN2A mutation profile with tumor mutation burden in head and neck cancer

Bosch R, Philips N, Surez-Prez JA, et al

The expression of ACO1, which regulates cellular iron levels, is also downregulated in IPF patients [208]

We found that the alterations in the blood of animal models were mainly characterized by decreases of amino acid concentrations

Additionally, although the thiolactone form has not been unequivocally identified in vivo , homocysteine could undergo intracellular cyclization into homocysteine thiolactone, which could be a major by-product of impaired homocysteine metabolism (Jakubowski, 1997