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Another recent analysis in nematodes finds that knockdown of specific V-ATPase subunits can promote autophagy activity and exert a beneficial effect on longevity 62

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In animal reproduction studies, intravenous administration of pemetrexed to pregnant mice during the period of organogenesis was teratogenic, resulting in developmental delays and increased malformations at doses lower than the recommended human dose of 500 mg/m2

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