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More specifically, the nuclear translocation of the YAP1 protein promoted the transcription of ACSL4 and TfR1 by binding directly to their promoters with TEAD4 and reduced the GPX4 protein level post-translationally by increasing its ubiquitination

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P.GrandasA.et al (2015)

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At low concentrations, ROS show beneficial effects by increasing wound healing, repairing processes, as well as prevent the growth of pathogens or germs by killing them whereas higher amount of ROS causes oxidative stress [5]