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Principal component analysis (PCA) was conducted using MATLAB R2015a (The MathWorks, Natick, MA, USA) with the PLS Toolbox version 8.1 (Eigenvector Research, Inc., Manson, WA, USA)

Value given are means SEM, with n = 5

Lysosomotropic agents, such as chloroquine (CQ), ammonium chloride (NH 4 Cl), and methylamine, accumulate in lysosomes, leading to lysosomal swelling and pH elevation 30,31,32

The Experiment: Pyxis Identifies Over 100 CHO Cell Metabolites in Under 15 Minutes To validate Pyxis in a bioprocessing setting, Matterworks partnered with Johnson & Johnson Innovative Medicine to profile CHO cell spent media and cell pellets collected daily over two 13-day, 10-L bioreactor runs

Typhilitis is associated with a very high mortality rate [97]