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In all three studies, citrulline malate was shown to significantly increase performance during upper- and lower-body multiple-bout resistance exercise performance

Perri et al., 2020)

In the animals given high doses of caffeine and paraxanthine cGMP, catalase and BDNF levels were all increased though this effect was seeen more strongly in those given paraxanthine

If you have a thyroid condition and/or any of the risk factors of B12 deficiency as outlined above, there is a very good chance that you are not properly absorbing B12, even if you eat a diet rich in animal proteins, so it is important to get tested if you suspect a deficiency