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Therefore, iron has a significant role in enhancing cellular ferroptosis sensitivity ( 2+ ) generated through intestinal absorption or degradation by red blood cells is oxidized to trivalent iron (Fe 3+ ), which becomes circulating iron by binding transferrin (TF) to form TF-Fe 3+ (Yang and Stockwell, 2008)

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Accelerated atherosclerosis: an extraarticular feature of rheumatoid arthritis