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Among these mechanisms, the plasticity of epigenetic modifications makes them attractive targets for research and therapeutic intervention

However, if that process is somehow interrupted you can end up with free radicals

J Clin Exp Ophthalmol

This can occur, for instance, through partial inhibition of replicative DNA polymerases with aphidicolin or under conditions of excessive generation of ROS 14 , which promote dissociation of the fork acceleration factor TIMELESS-TIPIN from the replisome in a manner dependent on the replisome-associated ROS-sensor PRDX2 51

A prime example is interferon (IFN), which may upregulate HLA class I heavy chains (2m, TAP1, TAP2, or Tapasin) and cause HLA-I to be downregulated when it is impaired (83)