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He had a meniscus tear in one knee that didnt require surgery and then injured his other knee

10.1111/nep.13114 15 RoffeyS

Neurochem., 2009, vol

The binding of the second substrate molecule at the S2 site triggers the conformational changes at the S1 site which leads to the permeation of the water molecules at the S1 site and facilitates the inward-open conformation