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It is now generally accepted that the photolysis of alkyl cobalamins results in formation of cob(II)alamin and alkyl radical pairs, similar to the intermediates from (AdoCbl)-dependent enzymatic catalysis

Human data: caution The only human data published to date are extremely limited: a 2024 pilot trial in 12 patients with interstitial cystitis treated with 10 mg of BPC-157 injected into the bladder wall, and a 2026 pharmacokinetic study in two healthy subjects (one 58-year-old man and one 68-year-old woman) receiving intravenous BPC-157

Distributed under the brand names Geref and Geref Diagnostic, it gained FDA approval in 1997 as a treatment for growth hormone deficiency but was discontinued in 2008 not out of concern for safety or lack of efficacy, but because of manufacturing difficulties.2 3 Yet it remains available in compounded form with a prescription from a licensed healthcare provider

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