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Suspected adverse reactions can be reported via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or the Yellow Card app)

This can promote antigen-presenting cell (APC) presentation and increase the binding affinity of the T cell receptor, leading to the activation of specific T cells

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Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]

Tirzepatide in its compounded form arrives as a lyophilized cake or powder inside a sealed glass vial