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S100A15 is an antimicrobial peptide and can increase the production and secretion of immunotropic cytokines such as TNF-, IL-6, and IL-8 in keratinocytes, leading to the development of cutaneous inflammation (21, 170)

doi: 10.1016/j.celrep.2018.04.053 229 GrilloMAColombattoS

ROS are located upstream of many inflammatory signaling pathways, upregulate the expression of other inflammatory factors, interfere with signaling pathways that regulate growth factors, and often alter signal transduction

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