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While positive muscle biopsy findings such as COX, SDH deficiency (Sonam et al., 2014), ragged red fibers (RRF), and atrophy of muscle fibers (Sofou et al., 2014) have been used as a diagnosis for LS, non-specific myopathic changes and negative findings have also been reported in patients with LS (Wei et al., 2018)

(4) Two Viable Translational Paths: First of all, it is necessary to give priority to including comparative functional indicators (target metabolite quantification, barrier markers, longitudinal changes in inflammation results) in clinical and preclinical studies to enhance the testability of the description of functional output to systemic inflammation

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