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Flow cytometry analysis (Fig

10.1080/09205063.2022.2056940 180 ShaoZ

Approximately 95% of primary bile acids are reabsorbed through the terminal ileum sodium-dependent bile acid transporter and enter the enterohepatic circulation, while the remaining 5% are metabolized by bile salt hydrolases and 7-dehydroxylases secreted by Bacteroides , Clostridium , Bifidobacterium , and Lactobacillus into secondary bile acids such as deoxycholic acid and lithocholic acid (Ridlon et al., 2016)

This problem strikes at the heart of our strategy, so it is important to give careful thought to the design of specific N-protective groups

Wightman, J.D