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The role of other molecules for this control is also important and may increase the complexity in the understanding of these mechanisms

While these gain- and loss-of-function experiments have helped reveal the myriad of roles of Wnt/-catenin signaling during development of the vestibular organs, it is important to point out that the levels of Wnt signaling also critically regulate morphogenesis as both inhibiting and activating modulators lead to a malformed vestibular system (Stevens et al., 2003)

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This review focuses on the pleiomorphic clinical presentations and the genetic substrate of FIC and proposes a possible diagnostic and therapeutic work-up for this group of diseases, considering the shared factors and therapeutic novelties that may affect them

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