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Impairment in peripheral conversion of thyroxine to triiodothyronine, alterations in receptor sensitivity, and inflammatory cytokine interference can produce a state of relative intracellular hypothyroidism

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Reference List Szeto HH et al., J Cardiovasc Transl Res 12, 398-407 (2019) Siegel MP et al., FASEB J 32, 4873-4883 (2018) Rabinovitch PS et al., J Clin Endocrinol Metab 104, 3347-3356 (2019) Campbell MD et al., J Clin Invest 129, 3748-3760 (2019) Nguyen et al., Biochemical Pharmacology 118, 6573 (2016) Fang et al., Cell Metabolism 28, 659672 (2018) Szeto HH et al., Nat Med 24, 1504-1512 (2018) Girotti et al., Journal of Neurochemistry 146, 13241335 (2017) Liu et al., Free Radical Biology and Medicine 130, 120128 (2018) Kumar et al., Journal of Clinical Investigation 128, 340354 (2020) Perez et al., Biomaterials 31, 872881 (2019) Schenk et al., Journal of Cardiovascular Pharmacology 61, 232242 (2018) Vasquez et al., Molecular Therapy 23, 12341246 (2020) Zhao W et al., Mol Med 25, 36 (2019) Park et al., Stem Cells Translational Medicine 8, 9921001 (2019) Parker et al., J Cell Physiol 234, 38723881 (2020) Marcinek DJ et al., Endocr Rev 42, 1-20 (2021) Marcinek DJ et al., Endocr Rev 42, 1-20 (2021) Harris et al., Journal of Immunology 199, 2134 (2017) Thompson et al., Free Radical Biology and Medicine 154, 5670 (2020) Peptide storage To ensure peptides remain stable and effective for laboratory use, follow these best practices for storage, tailored to maintain their integrity and prevent degradation, oxidation, and contamination: Short-Term Storage Refrigeration: Store peptides at 4C (39F) if they will be used within days to a few months

However, acutely after an ischemic stroke, elevated glutamate levels combined with changes in the Na + concentration trigger a reversal of the high-affinity Na + -dependent glutamate transporters, further contributing to the extracellular accumulation of glutamate (Longuemare and Swanson, 1995