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RES has been shown to inhibit autophagy through the regulation of the DJ-1 protein and its impact on the MEKK1/JNK signaling pathway ( RES protects the cardiovascular system by mechanisms that include defense against ischaemic-reperfusion injury, promotion of vasorelaxation, protection and maintenance of intact endothelium, anti-atherosclerotic properties, inhibition of low-density lipoprotein oxidation, suppression of platelet aggregation and oestrogen-like actions ( 3.7 Neuroprotection Research has revealed the potential neuroprotective benefits of RES, indicating its effectiveness in mitigating the effects of aging and neurodegenerative diseases, such as Parkinsons and Alzheimers disease

Among apoplastic enzymes, NADPH oxidases, amine oxidases, oxalate oxidases, and class III peroxidases contribute to ROS production, with the latter exerting contrasting effects peroxidative activity promotes wall stiffening, whereas hydroxylating activity facilitates wall loosening (Schmidt et al., 2016)