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Thung 2 and Bachir Taouli 3 , (1)Icahn School of Medicine at Mount Sinai, (2)Icahn School of Medicine at Mount Sinai (ISMMS), (3)Mount Sinai Hospital, New York, NY Background: Portal hypertension (PH), a common complication of liver cirrhosis, is defined as an elevated portal venous pressure gradient across the liver due to increased intra-hepatic vascular resistance

It is the rate-limiting enzyme of this metabolic pathway that supplies reducing energy to cells by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH)

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