The majority of the fish, excluding LMNA (W520G), matured into adulthood and were subsequently crossbred with wild-type (WT) fish to produce F1 offspring

many different animal species are studied in the laboratory, including terrestrial (land), aquatic (water), and microscopic animals Arrhythmia - abnormal heart rhythm Atria (singular: atrium) - the two upper chambers of the heart that receive blood from the veins and contract to force blood into the ventricles Ischemia (adjective: ischemic) - inadequate blood supply to an organ or tissue Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Placebo - a chemically inactive substance Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Test tube - a research experiment performed in a test tube, culture dish, or other artificial environment outside of a living organism

2 Mitochondrial long-chain fatty acid oxidation Mitochondrial fatty acid oxidation is an important pathway for maintaining energy homeostasis
Mahon and Dunne, 2018) or mucosal damage and gut permeability (Smith et al., 2007
Using a dominant negative mutation in TR (Thr PV/PV) mice, Araki and colleagues established the role of THR in hepatic lipid metabolism