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Description

The classic Bouwstra model describes the layer as a brick-and-mortar arrangement: corneocytes (the "bricks") are tightly packed flattened cells held together by intercellular lipids (the "mortar") arranged in lamellar bilayers

Mechanistically, PDI is involved in catalyzing the activation of NOS, which then leads to accumulation of cellular NO, ROS and lipid-ROS, and ultimately ferroptosis

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doi:10.1007/s12020-021-02644-x 99

Aftercare Routine: Proper aftercare, including sunscreen application and avoiding harsh products, can prevent pigmentation recurrence and ensure lasting consequences