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Medical treatments: Medication such as prescription and over-the-counter sleep aids can be useful as a short-term solution

At physiological pH, H 2 S (pKa ~7) exists predominantly (~70%) as the hydrosulfide anion (HS ) while the conjugate acid freely diffuses through biological membranes to access the catabolic machinery within mitochondria 4

Doi: Costa ACS, Brando AC, Boada R, Barrionuevo VL, Taylor HG, Roth E, Stasko MR et al (2022) Safety, Efficacy, and Tolerability of Memantine for Cognitive and Adaptive Outcome Measures in Adolescents and Young Adults with Down Syndrome: A Randomised, Double-Blind, Placebo-Controlled Phase 2 Trial

[DOI] [PMC free article] [PubMed] 108.Wasilko, D