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The most common adverse effects (AEs) reported were GI symptoms

Irisin exerts beneficial effects on mitochondrial biogenesis, lipolysis, and insulin sensitivity, and represents a promising therapeutic target in the management of metabolicalcoholic sarcopenia [120]

The defects in the 5-HT system lead to disorders such as depression, phobias, obsessive-compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder (Hirschfeld, 2000)