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There may be a role for human leukocyte antigen testing in prevention of severe adverse drug reactions, as shown in the following 2 examples: The HLA-B*5801 allele is associated with a markedly elevated risk of allopurinol hypersensitivity syndrome

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Circadian Rhythm Disruption as a Root Cause of DepressionCircadian clock gene variants in CLOCK, BMAL1, PER, CRY, NPAS2, and OPN4 interact with light exposure to disrupt hormones, sleep, and mood, increasing risk for depression, anxiety, and seasonal affective disorder

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STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells