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However, a significant proportion of patients are still refractory to pharmacological treatments, so the development of new drugs targeting the underlying mechanisms of UC is necessary to achieve optimal disease control

MEK inhibitor AZD6244 induces cell growth arrest and synergizes with Nutlin-3a-mediated cell death by upregulating p53 and PUMA levels in AML

The first studies investigating the role of physical exercise on ALS onset and progression demonstrated a beneficial effect achieved by an endurance training protocol in SOD1 G93A mice (Kirkinezos et al., 2003)

A systematic review of randomized controlled trials (RCTs) pinpointed the generally subpar methodological quality in the prevailing research on this topic [4]

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