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Strategies includeimmune checkpoint blockades, metabolic Tcell targeting therapy, therapeuticTcell vaccination, and adoptive transfer of genetically engineered CD8 + T cells, along with the combined usage of programmed cell death protein1/programmeddeath ligand1 (PD1/PDL1) inhibitors with mitochondriatargeted antioxidants.Given that targeting CD8 + T cells at various stages of hepatitis Bvirusinduced hepatocellular carcinoma (HBV + HCC) shows promise, we reviewedthe ongoing need for research to elucidate the complex interplay between CD8 + T cells and the liver microenvironment in the progression of HBV infection toHCC

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Proper handling of specimens ensures that results are reliable and reduces the risk of retesting, which can delay treatment

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