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Lowe, Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer

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As a central regulator of lipid metabolism, the PI3K/AKT pathway directly modulates key metabolic processes including fatty acid synthesis, catabolism, storage, lipid transport, and insulin sensitivity [37, 38]

(3) Old Age (60 years): reduced adaptability and higher deficiency risk Older adults have lower gut microbiota diversity and reduced fiber fermentation efficiency, making even mild nutrient deficiencies impactful: A cross-sectional study involving 297 elderly individuals aged 60 years and older (144 males and 153 females) was conducted to assess the relationship between zinc status and the presence of depression or anxiety, using validated scales and diagnostic tools

It was originally developed to treat type 2 diabetes, but recent studies have demonstrated that it can also help with weight loss and improved body composition