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Combination therapy is the current trend for the cure of diseases and therapeutic IC vaccines may be given in combination with drugs, or other immune regulatory factors, thereby achieving better therapeutic efficacy than either of the treatments alone

Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study

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Treatment typically includes four or more sessions, spaced apart by six to eight weeks

Past and present techniques, such as enzyme-assisted extraction (EAE), supercritical fluid extraction (SFE), and ultrasonic-assisted extraction (UAE), have been employed to maximise its extraction (67, 68)