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In microglia, butyric acid also activates the GPR109A-mediated signaling pathway to downregulate the NF-B signaling pathway, inhibits the production of pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and pro-inflammatory cytokines (TNF-, IL-1, and IL-6) in microglia, and prevents the onset and progression of neuroinflammation

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Alternatively, it is possible that the different clag paralogs form distinct channels that facilitate the uptake of different solutes