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Here are some common reasons a provider may recommend pairing B12 with tirzepatide: Patient is at a higher risk for vitamin B12 deficiency Patient has confirmed low B12 levels and is low in energy To monitor nutritional health during long-term GLP-1 treatment Important note: Vitamin B12 is not a weight-loss medication, nor does it enhance tirzepatides effects

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Second, medications that many older people take, like metformin for diabetes or proton-pump inhibitors for acid reflux, can also impact absorption. Are vegan or strictly vegetarian: Because most dietary intake of B12 comes from animal products, B12 supplements are recommended for people who eat a vegan diet or a vegetarian one with few eggs and dairy products

Both strategies are proving far more effective than single-target GLP-1 agonism