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It is triggered by HbS polymerisation and cumulative impacts of reactive oxygen species and free radicals, produced by intracellular hemoglobin metabolism (Jagadeeswaran and Rivers, 2017

Any side effects or unusual symptoms should be documented

This is especially so, as we observe that dimeric CBS 516525 also fits the two-site model even though this construct cannot form higher oligomers (Supplementary Figs

Adding a non-GLP-1 peptide is a different question, but it still requires caution