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As a supportive example of their theory, the authors observed that carbonylation of annexin A1, which shows anti-inflammatory, anti-proliferative and pro-apoptotic effects, leads to its degradation by the proteasome

Costunolide, a sesquiterpene lactone, demonstrated gut-brain regulatory effects in a chronic stress-induced IBS model by increasing levels of serotonin (5-HT), brain-derived neurotrophic factor, GluN2A, p-ERK1/2, and p-CREB in the hippocampus

CF patients characteristically exhibit recurrent infections/inflammations of the respiratory tract, which is consistent with an increase in oxidative stress