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Cabozantinib has received approval as a second-line therapy for RCC patients who have progressed on sunitinib, demonstrating superior efficacy compared to sunitinib in those with low or intermediate risk [206]

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455 Future research should elucidate how aberrant sensory afferent activity interacts with maladaptive CNS plasticity to initiate and sustain neuropathic pain

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Increases levels of Interleukin-2, Interleukin-12, and Interferon-gamma, cytokines, which are known to be crucial for the control of intracellular pathogens