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10.1186/s13148-014-0035-3 54 GuoX

Okuyama T, Shirakawa J, Nakamura T, Murase T, Miyashita D, Inoue R, et al

Each niche is shaped by distinct physical, chemical, and biological constraints [13]

The multifaceted status of DRE patients underscores the emphasis on non-pharmacological options, and therapies that target multiple mechanisms are likely to be more effective to treat DRE ( Clinical studies show that both modalities (VNS and KD) lead to a seizure frequency reduction (SFR) by at least 50% in half of the DRE patients

The observations discussed here derive primarily from animal-model studies and should be interpreted within appropriate scientific context