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Suppression of SPTBN2 or enhancement of HAR1A-mediated MYC degradation increases cisplatin sensitivity by inhibiting adaptive autophagy or directly triggering ferroptosis (119,120)

Chattopadhyay et al., 2007

Nutrients , 2019, 11: 2101 Abdillah A, Sonawane PM, Kim D, Mametov D, Shimodaira S, Park Y, Churchill DG

To determine the tolerable upper intake level (UL), the FNB selected adverse reproductive effects in rats as the most sensitive index of toxicity and applied a large uncertainty factor because animal data were used (2)

Enzymatic antioxidants, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, neutralize ROS, while non-enzymatic antioxidants like vitamin C, vitamin E, and glutathione protect against cellular damage