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Low basal level of CDNB activity observed in mock HepG2 cells likely resulted from low levels of other GST isoforms, since GSTP1 is not expressed in HepG2 cells (Sison-Young et al., 2015)

PS-MPs exacerbated oxidative stress in human vascular endothelial cells (EA.hy926) by downregulating the antioxidant enzyme heme oxygenase-1 (HO-1), disrupting mitochondrial potential, reducing tight junction protein ZO-1, and promoting apoptosis [123]

Podocyte activation of NLRP3 inflammasomes contributes to the development of proteinuria in lupus nephritis

DOI: Figure 3figure supplement 1

Severe alcoholic hepatitis (SAH) is characterized by the coexistence of systemic inflammation and immune dysfunction in the form of impaired immune cell responses to pathogens and their products, thereby leading to an increased susceptibility to infection