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Indeed, a rise in IGF-1 levels have been observed in multiple studies of IGF-1R blockade, which is attributed to the reduction in IGF-1-mediated inhibition of GH secretion 26,40

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snRNA-seq libraries were prepared using the 10X Genomics Chromium Next GEM Single Cell 3 Reagent Kits v.3.1 with loading of ~12,000 total nuclei per sample and sequenced on the Illumina HiSeq 4000 instrument