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In PD patients, reduced BH4 levels and GCH1 activity in the SN and striatum are associated with PD progression, indicating that aberrant BH4 metabolism contributes to PD pathogenesis (105)

Primers for SDM are described in Supplementary Data 1

The abundant lactate produced from glycolysis is divided into two pathways: intracellular accumulation inhibits proliferation and myofibroblast fibrogenesis-related gene expression, while inducing lipid accumulation and the expression of genes involved in lipogenesis (107)