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In humans, alterations in v-ATPase activity are implicated in multiple diseases, with complete loss of activity leading to embryonic lethality in higher animals 55

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Nuclei with large and dispersed halos of chromatin around the core were classified as non-fragmented (intact DNA), whereas those with small or no halos were considered fragmented

Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection