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Our results suggest that CBS of the TSS pathway plays an important role in maintaining cysteine levels under restricted cystine availability or excess hemin exposure, and CBS upregulation by DMF increases the cellular glutathione levels to protect against ROS and ferroptosis stress in SCD

Oxidative stress is involved in the mechanism of aging

Several studies have demonstrated that knockout or inhibition of these three synthesizing enzymes can effectively suppress the occurrence and progression of ferroptosis [3032]

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